We deploy advanced single-cell multi-omics technologies to decipher neoplastic hematopoiesis. Contact us to learn more!
Somatic mutations & cell identity.
We recently identified that the effects of somatic mutations vary as a function of cell identity in myeloid neoplasms (Nam, Kim, Chaligne, et al, Nature, 2019). We seek to understand the cell identity-defining mechanisms that cause the variabilities in the impact of somatic mutations. What are the cell intrinsic or extrinsic factors that dictate the mutations’ downstream effects?
Same mutation, different disease.
The same driver mutations in the hematopoietic system may result in distinct disease states (e.g. CALR mutations resulting in diverging phenotypes of essential thrombocythemia or myelofibrosis) or may not even progress to a disease, a state termed clonal hematopoiesis. We seek to understand the underlying molecular principles that determine the distinct phenotypic outcomes of the same driver mutations.