Publications — ANNA NAM LAB

Selected Publications

CALR-mutated cells are vulnerable to combined inhibition of the proteasome and the endoplasmic reticulum stress response

Jutzi JS, Marneth AE, Jiménez-Santos MJ, Hem J, Guerra-Moreno A, Rolles B, Bhatt S, Myers SA, Carr SA, Hong Y, Pozdnyakova O, van Galen P, Al-Shahrour F, Nam AS & Mullally A.

Nat Leukemia. 2022 Dec 06.

Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation

Nam AS, Dusaj N, Izzo F, Murali R, Myers RM, Mouhieddine TH, Sotelo J, Benbarche S, Waarts M, Federico G, Tahri S, Levine R, Abdel-Wahab O, Godley LA, Chaligne R, Ghobrial I, Landau DA.

Nat Genet. 2022 Sept 22.

Commentary: Voit RA, Sankaran VG. Multi-omics on our multitudes. Nature Genetics. 2022 Sept.

Commentary: Schnabel, J. Study sheds light on precancerous ‘clonal outgrowth’ in blood cells. Cornell Chronicle. 2022 Sept.

Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics

Nam AS, Chaligne R, Landau DA.

Nat Rev Genet. 2020 Aug 17.

DNA methylation disruption reshapes the hematopoietic differentiation landscape

Izzo F*, Lee SC*, Poran A, Chaligne R, Gaiti F, Gross B, Murali RR, Deochand SD, Ang C, Jones PW, Nam AS, Kim KT, Kothen-Hill S, Schulman RC, Ki M, Lhoumaud P, Skok JA, Viny AD, Levine RL, Kenigsberg E, Abdel-Wahab O, Landau DA. (*Equal contribution)

Nat Genet. 2020 Apr;52(4):378-387.

Exploring tumor clonal evolution in bone marrow of patients with diffuse large B-cell lymphoma by deep IGH sequencing and its potential relevance in relapse

Ma J, Redmond D, Miyaguchi A, Nam AS, Nie K, Mathew S, Elemento O, Tam W.

Blood Cancer J. 2019 Aug 21;9(9):69.

Somatic mutations and cell identity linked by Genotyping of Transcriptomes

Nam AS*, Kim KT*, Chaligne R*, Izzo F, Ang C, Taylor J, Myers RM, Abu-Zeinah G, Brand R, Omans ND, Alonso A, Sheridan C, Mariani M, Dai X, Harrington E, Pastore A, Cubillos-Ruiz JR, Tam W, Hoffman R, Rabadan R, Scandura JM, Abdel-Wahab O, Smibert P#, Landau DA#. (*Equal contribution; #Co-supervised)

Nature. 2019 Jul;571(7765):355-360.

Commentary: Raju S, Ye CJ. How mutations express themselves in blood-cell production. Nature. 2019 Jul;571(7765):329-330.

TARGET-seq Takes Aim at Cancer Evolution through Multi-omics Single-Cell Genotyping and Transcriptomics

Chaligne R, Nam AS, Landau DA.

Mol Cell. 2019 Mar 21;73(6):1092-1094.

Surf4 (Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum

Yin Y, Garcia MR, Novak AJ, Saunders AM, Ank RS, Nam AS, Fisher LW.

PLoS Biol. 2018 Aug 7;16(8):e2005140.

Assessment of the Utility of Cytology and Flow Cytometry of Cerebrospinal Fluid Samples in Clinical Practice

Nam AS, Giorgadze T, Tam W, Chadburn A.

Acta Cytol. 2018;62(2):130-136.

An intrasinusoidal extracavitary variant of primary effusion lymphoma

Nam AS, Tam W.

Blood. 2017 Aug 10;130(6):836.

Efficient trafficking of acidic proteins out of the endoplasmic reticulum involves a conserved amino terminal IleProVal (IPV)-like tripeptide motif

Nam AS, Yin Y, von Marschall Z, Fisher LW.

Connect Tissue Res. 2014 Aug;55 Suppl 1(0 1):138-41.